Fascination About akorn promethazine codeine

Infertility Chronic usage of opioids, like codeine, a part of promethazine HCl and codeine phosphate oral Answer, may perhaps result in diminished fertility in females and males of reproductive prospective.

Elevated pressure within your head (elevated intracranial force). Avoid using Promethazine Hydrochloride and Codeine Phosphate Oral Remedy When you have a head injuries or are already told that you've got improvements from the tissue of your brain (brain lesions) or increased strain in your head.

The approximated qualifications threat of important start defects and miscarriage to the indicated population is mysterious. All pregnancies Have got a qualifications chance of delivery defect, decline, or other adverse outcomes.

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Do not take any benzodiazepines or medicines that can cause drowsiness or sleepiness for the duration of cure with Promethazine Hydrochloride and Codeine Phosphate Oral Option. Talk to your Health care company for a listing of these medicines if You aren't positive.

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In certain kids and Grownups this takes place very quickly, and can result in you to prevent respiratory and result in Dying resulting from an overdose.

The codeine in promethazine HCl and codeine phosphate oral Option may perhaps induce spasm of your sphincter of Oddi, leading to a rise in biliary tract tension.

Steer clear of using promethazine HCl and codeine phosphate oral Option in people who will be getting a CYP3A4 inhibitor or CYP3A4 inducer. If concomitant utilization of promethazine HCl and codeine phosphate oral Answer with inhibitors and inducers of CYP3A4 is essential, check individuals for signs and indications that will reflect opioid toxicity and opioid withdrawal [see Drug Interactions (7.one, 7.2)].

The next significant adverse reactions are described, or described in greater depth, in other sections:

Many experiments examining the usage of promethazine in pregnancy didn't discover an association with an increased possibility of congenital anomalies. While in the couple of studies reporting an association, no steady sample of malformations was pointed out. Many of the studies, the two beneficial and destructive, were being limited by tiny sample measurement, recall bias and lack of information relating to dose and timing of publicity.

Monitor clients which has a heritage of seizure Problems for worsened seizure Command for the duration of promethazine HCl and codeine phosphate oral solution therapy.

Acute or serious bronchial bronchial asthma in an unmonitored location or in absence of resuscitative gear. (4)

Postmarketing cases of respiratory depression, such as click here fatalities happen to be claimed with utilization of promethazine in pediatric individuals.